Device for



Oct. 29, 1940. ERDMANN ET AL 2,219,544

DEVICE FOR FILLING AMPOULES AND THE LIKE Filed Aug. 19, 193B 2 Sheets-Sheet 1 ATTORNEYS Oct. 29, 1940. ERDMANN 2,219,544

DEVICE FOR FILLING AMPOULES AND THE LIKE Filed Aug. 19, 1938 2 Sheets-Sheet 2 ATTORNEYS 3 9; 756 VOETTE/Q claim 2, in which the device with which the slide is adapted to communicate comprises a long needle having a bore therethrough and which tion set up by said ampoule-creatin: device and moving upwardly and downwardly with said support but having no substantial movement in lateral directions.

HANS ERDMANN. WALTER VOETI'ER.

Patented 011.29, 1940 UNITED. STATES DEVICE FOR FILLING AMPOULES AND THE nan; Erdmann, Montclair, and Walter mar,

West Orange, N. 1., assignors to Schering Corporation, Bloomfield, N.

New Jersey J., a corporation of Application August 19, 1938, Serial No. 225,670

4 Claims.

'I'hisinvention relates to a device for measuring and depositing medicinal preparations in a powdered or crystalline form into ampoules, or the like, in measured doses. 5 Pharmaceutical manufacturers put up preparations which are distributed to the physician in powdered or crystalline form sealed in glass ampoules. The capacity of the ampoule is many times the volume of the amount of medicinal preparation inasmuch as the medicinal preparation, before injection into the patient, must be dissolved or suspended in distilled water or other solution. The physician in the course of mixing the medicinal preparation and the liquid, breaks on the top of the ampoule containing the medicinal preparation andlikewise breaks off the top of another ampoule containing the liquid. The

of the medicinal preparation represents a stand-- ard dose and the device of this invention measures the quantity of the dose and deposits the same into an ampoule. The ampoule is a fragile and small, long-necked container and it is important that the ampoule be not cracked in the course of depositing the medicinal preparation therein. It is also of importance that the dose be measured with some exactness to conform to the standard dosage for the particular medicinal preparation being put up. Such medicinal preparations are put out and used in small dosages, the weight of each dosage in many instances being 0.1 of a gram and sometimes less. I

It has been found to be somewhat diflicult .to

handle these small quantities of materials, par-- In the drawings, Fig. 1 is a side view of the device; 'Fig. 2 is an opposite side view partly in section; Fig.3 is a plan view of Fig. 2; Fig. 4

. The base I carries an electrical device 2 capable, when electrically actuated, of setting up vibrations, preferably at the rate of sixty impulses a second, which can readily be obtained if the instrument is connected with a line delivering a hundred and ten volts A. C. A magnetic coil 1 associated with a core 4 has been found to be satisfactory for-delivering the required vibrations or impulses. The U-shaped strip 5 secured to the base I has a laterally extending arm 6 which extends over the core 4 in spaced relation thereto.

The vibratingor impulse-producing device is connected by a suitable line to a source of alternating current (not shown). The shaft of the electric motor I is secured to the shaft 8 of the speed reducer 9 by a collar Ill. The parallel driven shaft ll carries the cam l2. An arm l3, pivoted at. It to the base I, carries a roller I! which is engaged periodically by the cam l2 in the course of its cycle. The arm I3 is drawn'under tension of. the spring l6 toward the face of the cam l2 in order that the roller I! shall at all times engage the face of the cam l2 and'reciprocate under the impulse of the varying high and low points of the cam. A support I1 is joumalled in the bearing block it secured to the posts I! mounted on the top of the speed reducer. The support ll at one end thereof carries upper and lower plates 20 and 2| which are spaced apart to accommodate a slide 22 interposed between them. The slide 22 is provided with a hub 23 which fits into recesses 24 in the plates 20 and 2!. A shaft 25 passes through the recesses 24 and fits securely in the bearing 23 and is supported by the bearings 26, secured to the plates 202|. The coil springs 21, retained under pressure by the plates 28 and pins 29, unite the top and bottom plates 20 and 21 and the slide 22 resiliently and thus provide for movement of the slide 22 with the shaft 25 in the bearing 26. The lower plate 2i extends beyond the outer edge of the plate '2. and is provided with a recess 30 connecting with an elongated hollow needle 3|. The slide 22 is provided with a measuring cup 32 opened at both ends, the lower opening whereof ,is closed by the top surface of the plate 2| whenever'the slide is in a position other than in alignment with the needle 3|. The measuring cup 32 is of such capacity as to contain, when filled,v a given amount of the medicinal preparation to provide a single dose" or a measured quantity ,for each ampoule. 

